Many woman are having issues that have had the vaccine or have come in contact with someone that has had it. Could Shedding be a thing? We have shown that RNAi against a specific gene delivered to the hypothalamus via intracerebral administration disrupts female reproductive cyclicity in both rats and nonhuman primates. Because in this latter species ovulation was blocked, the assumption is that silencing of this single gene resulted in a state of infertility. We anticipate that devising delivery systems able to selectively, or even specifically, target the hypothalamus upon systemic administration should provide the tools to silence genes essential for reproduction in a non-invasive, effective and sustained manner in dogs and cats. We also anticipate that these studies will provide the basis for new delivery strategies to the brain for basic research purposes and emerging therapies.